Deep insights. Simply put
Carefully curated. Deeply researched. Free of ads and shackles.
There are brilliant content producers with the finger on the pulse. So we won’t regurgitate the news just to keep up with the crowd, except if the news needs an urgent second opinion. And this is not a rarity. We take our time to see through commercial biases, and noodle on the nuances behind the headlines. Always in an easily digestible form. An individual human may be pear-shaped but is never bell-shaped - meaning, statistical evidence for whole populations may not fit well with you if you’re an edge case or working in extremes. Like many of our patients. While on the programme or alumni membership we’ll take the topics you ask us about and tailor what it means to those like you. And while we use AI tools to help us search and type faster, rest assured, we don’t rely on anyone except the experts.
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We geek out on:-
Preventive & therapeutic medicine
Leadership & relationships
Health-span research
Human Performance Science
Nutrition and 'Notrition' (fasting) and Nootrition (cognitive enhancement)
Sleep, Jetlag and circadian biology
Fitness & Physique
All things Psyche...
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Mitigating the cardiovascular risk of stress and depression
Do you worry about the long term consequences of sustained stress or depression on your health
Is it possible to mitigate the known risk of heart attacks due to chronic stress or depression 💔?
This could be highly relevant for many entrepreneurs and founders:
👉93% of founders in our analysis reported having felt overwhelmed with pressure or stress from responsibilities, circumstances or relationships 🤯
👉55% of founders were in the lowest quartile for cardiorespiratory fitness
Microplastics and Nanoplastics in Atheroma and Cardiovascular Events
In a recent publication in The New England Journal of Medicine, researchers have established a worrisome connection between the presence of microplastics and nanoplastics (MNPs) in atherosclerotic plaques and an increased risk of cardiovascular incidents. Highlighting MNPs as both enduring environmental contaminants and significant health risks, this study underscores the critical need for managing our exposure to these particles.
In this article Dr Andrew delves into the recent findings, providing insights on practical measures to minimize exposure and mitigate the health impacts of MNPs. Steering clear of alarmism, he advocates for a balanced, integrated approach that combines reducing MNP exposure with broader cardiovascular health strategies, including lifestyle changes and preventive healthcare.
Wonder Drug
Expedition Finse: The explorers return fresh from their recent adventures in Norway.
Time-restricted eating for cardiovascular health: controversy and complexity.
IF, recent headlines are to be believed, time restricted eating (TRE) may not be so good for our hearts, despite many people successfully improving body composition and cardiometabolic markers using this dietary strategy.
Blood Flow Restriction Training: Resistance training for time poor individuals
Blood Flow Restriction (BFR) training is making profound impacts on fitness routines worldwide, proving to be an adaptable and efficient method for achieving health and fitness goals amidst busy lifestyles and rehabilitation needs.
The technique employs strategic blood flow reduction to muscles during low-intensity exercises, enabling significant gains in muscle strength and size without the need for heavy lifting. Ideal for rehabilitation and those with limited gym access or time, BFR training is reshaping the way we think about fitness and recovery.
In this article, Dr Andrew explores the many benefits of this new approach to muscle development and rehabilitation, from enhanced muscle hypertrophy and strength to improved cardiovascular endurance and faster recovery times. Crucially, he will also guide you through the correct implementation of BFR training to ensure a safe and more effective workout.
Too much of a good thing? The latest on omega 3 for heart health
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued guidance urging caution over the potential link between omega-3 intake and atrial fibrillation, reigniting discussions around the health implications of these fatty acids.
Despite the concerns, the myriad of benefits of omega-3, particularly eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, continue to be a topic of interest for both cardiovascular health and beyond.
This article looks at the latest research and offers a comprehensive analysis of recent studies and trials, assessing the risks and benefits of omega-3, its impact on conditions such as atrial fibrillation, and its broader implications for public health recommendations.
Feeding the Mind: How the Gut Microbiome Influences Mental Health
January can be a difficult month for many of us, especially in the UK where the days are short, cold and often grey and the nights long. Nutrition plays a critical role in maintaining good mental health, and it is the trillions of gut microbes in our gut that help to keep us happy. The human gut microbiome, a complex ecosystem of microorganisms residing in our digestive tract, has emerged as a key player in factors influencing our mental health.
Exhausted but INSPIRED
A year ago today, our team accomplished an incredible feat by reaching the South Pole. The INSPIRE expedition taught us about the limits of human endurance, the power of resilience and teamwork, and how wearables enable studies into health and performance in the most extreme environments. We also discovered that women outperform men in certain aspects of hyper-endurance and learned invaluable lessons about teamwork and perseverance in the face of adversity.
Reflecting on this life-changing experience, and 40 year ambition, I realised how much it has impacted my approach to business, relationships, and life in general. Co-leading the INSPIRE expedition taught me a lot about how to be a better leader, doctor and carer, and face up to challenges head on, remaining optimistic. We have translated many of the INSPIRE findings into our WellFounded Health and performance programmes for Founders, CEOs and their investors. The results are most promising and illuminate how extreme environments research is specifically relevant to the work and lives of entrepreneurs.
I am deeply grateful for the lessons learned during this unforgettable journey and am grateful to be able to share them with you.
Small Steps, Big Wins: Rethinking New Year's Resolutions for Lasting Change
Resolutions are easy to make and hard to keep! Why do we feel that it must be a new day, a new month and a new year to start something new or to reform bad habits?
By the beginning of February, 80% of resolutions will have failed. WHY? Because most resolutions are centred around deprivation and negative self-talk. Go big or go home, all or nothing, now or never thinking are also a recipe for failure. Behavioural change is not just about willpower and motivation - they don’t work and that has been proven by multiple studies.
Successful behavioural change centres around making small, consistent and achievable changes and then ensuring that we fully celebrate the win. Creating positive emotions around changes leads to better success. It may sound silly to celebrate our wins but that link to positivity leads us to want to continually recreate that winning formula.
And because change is hard, we need to make new habits easy.
What about reframing and adding in new habits or changes instead of depriving yourself or taking away your pleasures?
Here are a few ideas…
Refocusing on Health: Building Muscle, Mastering Zones, and Metabolic Balance in the New Year
“First tell yourself what kind of person you want to be, then do what you have to do. For in nearly every pursuit, we see this to be the case. Those in athletic pursuit first choose the sport they want to, and then do that work.” Epictetus.
As the festive season concludes and we enter the new year, many of us face the challenge of re-engaging with our normal routines or turning over a new leaf. We still carry the guilt of that last mince pie or overindulging over the holidays. It’s time to shed that guilt and worry that we cannot change and think about what we can implement to start initiating change for the better. This period of reinitiation offers a unique opportunity to refocus on long-term health goals rather than immediate performance metrics.
Unlocking the Power of Oxytocin: The Importance of Cherishing Family Time
The festive season for many is a time of joy, reflection, and connection, particularly within the family unit. It's a period that underscores the importance of nurturing relationships between parents and children. In this article, Dr Andrew reflects on the invaluable role of family in our lives and the profound impact that spending quality time with family has on both adult and child to the overall well-being and development of both individuals. He explores the significant physiological, emotional, and developmental benefits of shared moments together, reminding us that these will resonate long after the holiday decorations are put away.
Why is Maintaining Weight Loss so Hard?
Navigating Sleep and Brain Health: Insights from the UK Biobank Study
In the ever-evolving field of sleep research, the recent study published in the journal 'Sleep' titled, "Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort" marks a significant leap in understanding the complex interplay between sleep habits and brain health. Dr Andrew Crockett delves into this research and provides a critical analysis; shedding light on a subject of paramount importance for founders and professionals who grapple with the delicate balance between work demands and rest.
Folli or For Real? Follistatin gene doping. The story so far.
In the rapidly evolving world of health and biotechnology, a new topic is capturing the attention of fitness enthusiasts and medical professionals alike: Follistatin gene therapy. This intriguing therapy, which has gained notoriety through figures like Dave Asprey and Bryan Johnson, is stirring up discussions across various circles. Why is this molecule so captivating, and what does it mean for muscle development?
The Paradox of Ultra-Longevity: A Responsible Approach to Extending Healthspan
In an age where science fiction edges closer to reality, the quest for extending human life beyond its natural bounds has captivated the imagination of many. Yet, with this enthralling possibility comes a labyrinth of ethical, environmental and social implications that demand our attention. In light of the recent article in the Times, Dr Jack Kreindler shares his reflections on the the current drive towards ultra longevity and invites us to consider its implications for humanity and the Earth, unfolding the intricate tapestry of what it means to live a life extended, not just in years, but in vitality and purpose.
Walking: The Benefits
In today's fast-paced world, where our lives are often consumed by sedentary routines, the simple act of walking emerges as a powerful antidote to various health challenges. A natural and accessible form of exercise, walking not only reconnects us with the rhythm of life but brings a multitude of health benefits. Join our exercise physiologist, Tom Cowan as he shares the many benefits of this everyday activity, shedding light on its remarkable impact on both physical and psychological well-being and shares practical insights into how to harness its benefits and elevate it from a simple stroll to a meaningful and effective cardiovascular workout.
Ever Closer to Cracking Cancer’s Code?
In frank conversation with four pioneers cracking Cancer’s code
It was a privilege, as ever, to curate and chair another future of medicine panel for Founders Forum Group. This time for Founders Forum North America Summit in Brooklyn, New York. A notable thank you to Carolyn Dawson OBE and Brent Hoberman CBE for hosting us all.
Four pioneers came to speak on our main stage panel from near and far to illuminate the very bleeding edge of cancer prevention, detection and next generation therapeutics. All of which will make the life of a future oncologist very different. Reed Jobs of cancer dedicated deep tech fund Yosemite.co, Emi Gal of MRI cancer prevention pioneers Ezra, James Peyer, PhD of Cambrian Bio (who I stole from the Founders Forum Longevity round table, cancer being a disease of ageing no less) and last but not least the extraordinary Azra Raza from Columbia University an Oncologist of the decades long sacrifice, compassion and commitment like no other who I hold claim of being number one fan.
Sleep consistency vs duration: the underdog wins.
The emerging science of sleep has long emphasized the importance of sleep duration, typically recommending seven to nine hours per night for optimal health. However, the latest study published a few weeks ago in the journal Sleep offers a game-changing perspective. This isn't about clocking in more hours under the covers; it's about the rhythm and regularity of your sleep pattern.
Reduce hunger, boost mood and improve sleep with one simple tool: Time.
A study presented this week at the European Nutrition Conference by King’s Colege London highighted a study that sheds new light on the potential benefits of extending our morning fast that little bit further. The study, which is the largest of its kind outside of a clinical setting, has provided insightful findings on the benefits of eating within a 10-hour window and fasting for the remaining 14 hours. The results were presented at the European Nutrition Conference and drew upon data from users of the ZOE Health app.
Innovating Healthcare: Reflections from the CNS Summit and Beyond
Dr Jack Kreindler shares his reflections on last week’s CNS Summit. Hosted by the distinguished AMIR KALALI, MD, this summit offered an exceptional platform to discuss groundbreaking advancements in healthcare. Dr Jack’s opening keynote, supported by key sponsor Medable, Inc., delved into the innovative ways we're tackling healthcare barriers through technology and community. From the insights gained in our INSPIRE South Pole expedition to the potential of female physiology in hyper-endurance, these experiences are shaping the future of healthcare. Here, Jack explores these transformative ideas and their far-reaching implications for our industry and beyond.