Deep insights. Simply put
Carefully curated. Deeply researched. Free of ads and shackles.
There are brilliant content producers with the finger on the pulse. So we won’t regurgitate the news just to keep up with the crowd, except if the news needs an urgent second opinion. And this is not a rarity. We take our time to see through commercial biases, and noodle on the nuances behind the headlines. Always in an easily digestible form. An individual human may be pear-shaped but is never bell-shaped - meaning, statistical evidence for whole populations may not fit well with you if you’re an edge case or working in extremes. Like many of our patients. While on the programme or alumni membership we’ll take the topics you ask us about and tailor what it means to those like you. And while we use AI tools to help us search and type faster, rest assured, we don’t rely on anyone except the experts.
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We geek out on:-
Preventive & therapeutic medicine
Leadership & relationships
Health-span research
Human Performance Science
Nutrition and 'Notrition' (fasting) and Nootrition (cognitive enhancement)
Sleep, Jetlag and circadian biology
Fitness & Physique
All things Psyche...
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Retatrutide the wonder drug: What's Established, What's Plausible, What's Still a Hypothesis
On Thursday 21 May 2026, Eli Lilly announced that participants in TRIUMPH-1, the first Phase 3 trial of retatrutide in obesity, lost an average of 28.3% of their body weight at 80 weeks on the 12 mg dose, with 45.3% losing at least 30% of their starting weight [1]. Within hours the figure was being framed as the largest sustained pharmacological weight loss yet recorded, comparable to bariatric surgery.
That number is real. It is also one number, from one indication, from one trial. Retatrutide has been studied in at least eight different conditions, and what we know about each is significantly uneven. Treating the molecule as a single story misses what the trials actually say.
The Physiology of Breath: Separating the clinical mechanics of nasal breathing from the wellness narrative
Breathwork has become mainstream wellness. The case for it is now firmly established in bestselling books, viral sleep hacks, and a steady stream of people asking about mouth taping, BOLT scores, and CO2 tolerance training. If you're genuinely curious about whether the air we move through our face via one route or another is something we should be optimising, read on.
Salt, Sweat, and Smart Hydration
Staying hydrated sounds simple, until you try to perform at your best in real-world heat. Too little fluid and you overheat; too much and you dilute your body’s chemistry. The truth is, hydration isn’t just about water - it’s about timing, composition, and context. This week Dr Andrew breaks down the science behind fluid balance, salt, and performance, cutting through the marketing noise with clear, evidence-based strategies that work in the lab and on the trail.
Beyond Optimisation: How Extreme Environments Build Ultimate Resilience
For a generation of trailblazers optimised to the minute, tracking every biomarker from glucose to HRV, a question emerges: what happens when the data runs out? While optimising physiology is crucial, the unquantifiable resilience needed to navigate true uncertainty is forged, not measured. For this, we must look beyond the dashboard and into the extremes of nature.