Deep insights. Simply put
Carefully curated. Deeply researched. Free of ads and shackles.
There are brilliant content producers with the finger on the pulse. So we won’t regurgitate the news just to keep up with the crowd, except if the news needs an urgent second opinion. And this is not a rarity. We take our time to see through commercial biases, and noodle on the nuances behind the headlines. Always in an easily digestible form. An individual human may be pear-shaped but is never bell-shaped - meaning, statistical evidence for whole populations may not fit well with you if you’re an edge case or working in extremes. Like many of our patients. While on the programme or alumni membership we’ll take the topics you ask us about and tailor what it means to those like you. And while we use AI tools to help us search and type faster, rest assured, we don’t rely on anyone except the experts.
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We geek out on:-
Preventive & therapeutic medicine
Leadership & relationships
Health-span research
Human Performance Science
Nutrition and 'Notrition' (fasting) and Nootrition (cognitive enhancement)
Sleep, Jetlag and circadian biology
Fitness & Physique
All things Psyche...
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Navigating Sleep and Brain Health: Insights from the UK Biobank Study
In the ever-evolving field of sleep research, the recent study published in the journal 'Sleep' titled, "Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort" marks a significant leap in understanding the complex interplay between sleep habits and brain health. Dr Andrew Crockett delves into this research and provides a critical analysis; shedding light on a subject of paramount importance for founders and professionals who grapple with the delicate balance between work demands and rest.
Folli or For Real? Follistatin gene doping. The story so far.
In the rapidly evolving world of health and biotechnology, a new topic is capturing the attention of fitness enthusiasts and medical professionals alike: Follistatin gene therapy. This intriguing therapy, which has gained notoriety through figures like Dave Asprey and Bryan Johnson, is stirring up discussions across various circles. Why is this molecule so captivating, and what does it mean for muscle development?
The Paradox of Ultra-Longevity: A Responsible Approach to Extending Healthspan
In an age where science fiction edges closer to reality, the quest for extending human life beyond its natural bounds has captivated the imagination of many. Yet, with this enthralling possibility comes a labyrinth of ethical, environmental and social implications that demand our attention. In light of the recent article in the Times, Dr Jack Kreindler shares his reflections on the the current drive towards ultra longevity and invites us to consider its implications for humanity and the Earth, unfolding the intricate tapestry of what it means to live a life extended, not just in years, but in vitality and purpose.
Walking: The Benefits
In today's fast-paced world, where our lives are often consumed by sedentary routines, the simple act of walking emerges as a powerful antidote to various health challenges. A natural and accessible form of exercise, walking not only reconnects us with the rhythm of life but brings a multitude of health benefits. Join our exercise physiologist, Tom Cowan as he shares the many benefits of this everyday activity, shedding light on its remarkable impact on both physical and psychological well-being and shares practical insights into how to harness its benefits and elevate it from a simple stroll to a meaningful and effective cardiovascular workout.
Ever Closer to Cracking Cancer’s Code?
In frank conversation with four pioneers cracking Cancer’s code
It was a privilege, as ever, to curate and chair another future of medicine panel for Founders Forum Group. This time for Founders Forum North America Summit in Brooklyn, New York. A notable thank you to Carolyn Dawson OBE and Brent Hoberman CBE for hosting us all.
Four pioneers came to speak on our main stage panel from near and far to illuminate the very bleeding edge of cancer prevention, detection and next generation therapeutics. All of which will make the life of a future oncologist very different. Reed Jobs of cancer dedicated deep tech fund Yosemite.co, Emi Gal of MRI cancer prevention pioneers Ezra, James Peyer, PhD of Cambrian Bio (who I stole from the Founders Forum Longevity round table, cancer being a disease of ageing no less) and last but not least the extraordinary Azra Raza from Columbia University an Oncologist of the decades long sacrifice, compassion and commitment like no other who I hold claim of being number one fan.
Sleep consistency vs duration: the underdog wins.
The emerging science of sleep has long emphasized the importance of sleep duration, typically recommending seven to nine hours per night for optimal health. However, the latest study published a few weeks ago in the journal Sleep offers a game-changing perspective. This isn't about clocking in more hours under the covers; it's about the rhythm and regularity of your sleep pattern.
Reduce hunger, boost mood and improve sleep with one simple tool: Time.
A study presented this week at the European Nutrition Conference by King’s Colege London highighted a study that sheds new light on the potential benefits of extending our morning fast that little bit further. The study, which is the largest of its kind outside of a clinical setting, has provided insightful findings on the benefits of eating within a 10-hour window and fasting for the remaining 14 hours. The results were presented at the European Nutrition Conference and drew upon data from users of the ZOE Health app.
Innovating Healthcare: Reflections from the CNS Summit and Beyond
Dr Jack Kreindler shares his reflections on last week’s CNS Summit. Hosted by the distinguished AMIR KALALI, MD, this summit offered an exceptional platform to discuss groundbreaking advancements in healthcare. Dr Jack’s opening keynote, supported by key sponsor Medable, Inc., delved into the innovative ways we're tackling healthcare barriers through technology and community. From the insights gained in our INSPIRE South Pole expedition to the potential of female physiology in hyper-endurance, these experiences are shaping the future of healthcare. Here, Jack explores these transformative ideas and their far-reaching implications for our industry and beyond.
Musings on Music, the Mind and Medicine
Have you ever wondered why you feel a rush of excitement when your favourite pop song comes on the radio or feel a sense of calm when listening to a soothing classical piece? Dr. Jack Kreindler sheds light on the profound effects of music on our brains and bodies.
A passionate music enthusiast, rather than a music scientist, he delves into the fascinating world of music’s influence on human (and even non-human) biology, exploring the science behind why music affects us so deeply.
Drop your blood glucose and improve your mood: A Simple Change to Combat the Risks of Prolonged Sitting
In the quest to mitigate the health risks associated with prolonged sitting, a recent study sheds light on the benefits of breaking up sedentary time with short, light-intensity walking breaks. It is already well reported that increased time sitting, above 6 to 8 hours per day of total sitting time and 3 to 4 hours per day of TV viewing time, are associated with greater risks of all-cause and cardiovascular deaths.
A New Hope for Cancer
From hopeless in 1996 to Hope in AOH1996: The inspiring City of Hope Hospital’s own cancer research department has possibly achieved something that no other pharma company has managed since chemotherapy began in the mustard gas days. It’s an oral therapy candidate called AOH-1996 (not in humans yet).
How to put on muscle: Why less might be more.
Blood flow restriction (BFR) training is a relatively new training method, but it has quickly gained popularity among athletes and fitness enthusiasts alike. This is because BFR has been shown to be very effective at increasing muscle strength and size, even when using light weights.
The Circadian Advantage: How to Make Smarter Investment Decisions with Your Body Clock
Circadian rhythms are our natural sleep-wake cycles, our body clock. They play a significant role in every cell in our body but also in our cognitive function. Within waking hours, an individual reaches peak performance during their circadian “acrophase”, and their performance drops during their “circadian nadir”. The timing of this window of optimal alertness classifies individuals as either a morning lark or night owl chronotype. Larks experience peak cognitive performance in the morning and the opposite is true of owls, who perform better in the evening. Research has shown that circadian rhythms can thus impact investment decision-making.
Freeze your eggs or freeze your career?
Delaying building relationships and families is a common side effect when getting a big dose of cash and building a business. Younger female entrepreneurs have to think about this all the time. Investors should be more aware of this supra-added issue over the ‘let’s do it later’ family planning trend. Is the empowering option to freeze also promoting risky delays while making the IVF industry thrive.
VILPA: The Secret to a Longer Life Could Be in Your Daily Routine
New research finds that just three to four one-minute bursts of vigorous intermittent lifestyle physical activity (VILPA) each day is associated with large reductions in the risk of premature death, particularly from cardiovascular disease.
Mental Wellness for Founders and Building Resilience
While building WellFounded, we have seen first-hand how modern society profoundly influences our mental well-being, especially for entrepreneurs where the stresses and pressures can impact their entire business ecosystem. We don't build businesses in a vacuum and it is entirely normal that we bring with us the weight of modern stress and expectation. Our role at WellFounded is to assist where this becomes overwhelming and I think some of our founders might be surprised to learn how much this involves stress management and conflict resolution. However, we believe that if we better understand the effect that stress can have on our bodies' chemical balances and in turn our decision-making we can build healthy environments for both founders and their teams.
Japan: A glimpse into a hyper ageing future society
Everyone dreams of healthy longevity. But is it really a blessing when the delicate, older leaves on the tree are relying on ever fewer strong, young branches?
Sunshine In a Pill: Can We Truly Bottle the Benefits of Light Exposure?
Decoding Genetic Tech
CRISPR-Cas9 works like molecular scissors in a way that can cleave the DNA allowing it to trigger different types of modifications that lead to a change of code in the DNA
