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Rapid amyloid clearance in hours: what this 2025 mouse study shows us
Could the fastest way to treat Alzheimer’s disease be not to attack plaques in the brain, but to restore the brain’s clearance plumbing?
Alzheimer’s disease has long been one of medicine’s most stubborn challenges. For decades, scientists have approached this battle on two fronts: stopping the buildup of amyloid plaques in the brain, and getting drugs past the brain’s ultra-strict protective barrier, the Blood-Brain Barrier (BBB).
A recent 2025 paper in Signal Transduction and Targeted Therapy reported a striking finding in an Alzheimer’s mouse model: using nanotechnology, they were able to half brain amyloid within 2 hours, and importantly, restored spatial learning and memory in the mice, comparable to their normal peers.