Deep insights. Simply put
Carefully curated. Deeply researched. Free of ads and shackles.
There are brilliant content producers with the finger on the pulse. So we won’t regurgitate the news just to keep up with the crowd, except if the news needs an urgent second opinion. And this is not a rarity. We take our time to see through commercial biases, and noodle on the nuances behind the headlines. Always in an easily digestible form. An individual human may be pear-shaped but is never bell-shaped - meaning, statistical evidence for whole populations may not fit well with you if you’re an edge case or working in extremes. Like many of our patients. While on the programme or alumni membership we’ll take the topics you ask us about and tailor what it means to those like you. And while we use AI tools to help us search and type faster, rest assured, we don’t rely on anyone except the experts.
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We geek out on:-
Preventive & therapeutic medicine
Leadership & relationships
Health-span research
Human Performance Science
Nutrition and 'Notrition' (fasting) and Nootrition (cognitive enhancement)
Sleep, Jetlag and circadian biology
Fitness & Physique
All things Psyche...
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NAD⁺ in humans: can you raise it and does it matter clinically
NAD⁺ biology is strong.
That is exactly why the marketing gets ahead of the evidence.
Human trials show you can raise a blood marker.
They do not yet show reliable functional benefit in healthy older adults.
IV NAD⁺ sits lowest on the evidence ladder, despite the loudest claims.
The science behind NAD⁺ and ageing is genuinely interesting. That is part of the problem.
NAD⁺ has become one of the most talked about ideas in longevity. NAD⁺ is not a single-purpose molecule. At the most basic level, it helps cells turn food into usable energy.
But it also does more than that.
It is linked to aging in several critical ways:
to repair damage that accumulates in your DNA every day
to power a family of proteins (sirtuins) that regulate how genes are read
mitochondrial dysfunction
chronic inflammation
The theory goes that NAD⁺ falls with age, supplements raise it, and raising it should improve energy, metabolism, brain function, and slow down the ageing process.
Creatine for female health: Don’t fall into the trap of thinking it’s just for elite athletes
Once seen as a supplement exclusively for male bodybuilders, creatine is so much more than a tool for athletic performance. The latest research is revealing its powerful benefits for a much broader audience, especially women. From boosting brain health and mood to strengthening bones and muscles, creatine offers a wide range of benefits that can support a healthy, high-performing life. Dr Ran Crooke looks at the science behind creatine and explores why it's a game-changer for women at every stage of life.
The NAD+ Puzzle: Why Lifestyle Still Trumps Supplements
The longevity industry is mesmerised with NAD+. We see IV drips and expensive supplements everywhere.
But what if the key to cellular energy, resilience, and peak performance isn't in a bottle, but in your daily habits?
This week, Dr Andrew breaks down the science of NAD+ and reveals why lifestyle surpasses supplements every time.